News
Nov. 2020: Naima's paper 'Does diversity beget diversity in microbiome?' is now out in eLife, along with Olga's preprint on single-colony sequencing of Microcystis.
Oct. 2020: Two new preprints out! Inès et al. on V. cholerae hypermutation and evolution within patients and Arnaud on pangenome sequence evolution in the human microbiome.
Sept 2020: Our analysis of SARS-Cov-2 genomes from Québec is now on virological, led by Carmen and the CoVSeQ team
Nov. 2020: Naima's paper 'Does diversity beget diversity in microbiome?' is now out in eLife, along with Olga's preprint on single-colony sequencing of Microcystis.
Oct. 2020: Two new preprints out! Inès et al. on V. cholerae hypermutation and evolution within patients and Arnaud on pangenome sequence evolution in the human microbiome.
Sept 2020: Our analysis of SARS-Cov-2 genomes from Québec is now on virological, led by Carmen and the CoVSeQ team
Why Microbial Evolutionary Genomics?
Most of the genetic and metabolic diversity that exists on earth – and has existed for billions of years – is microbial. Arguably more impressive than the sheer quantity of microbial diversity is its dynamic nature: microbes are constantly evolving and adapting. Our ongoing research tracks evolving microbial populations in real time, using whole-genome and whole-community DNA sequencing to understand their evolution and predict how they adapt to changing environments. For example:
(1) freshwaters subject to seasonal cyanobacterial blooms, (2) the human gut, focusing on cholera infections, (3) the evolution and ecology of antibiotic resistance, (4) semi-natural mesocosms at LEAP. Pourquoi la Génomique Microbienne Évolutive ? La plupart de la diversité génétique et métabolique qui existe - et a existé depuis des milliards d'années - est de nature microbienne. Plus impressionnant que l'énorme quantité de diversité microbienne est sa nature dynamique: les microbes sont constamment en train d'évoluer et de s'adapter à leur environnement. Notre programme de recherche suit l'évolution des populations microbiennes en temps réel, en utilisant le séquençage de génomes (de souches individuelles) et de métagénomes (l'ADN de communautés entières) afin de comprendre leur évolution et prédire comment ils s'adaptent à des environnements changeants. Par exemple: (1) les eaux douces qui subissent des proliférations saisonnières de cyanobactéries, (2) l'intestin humain, en se concentrant sur les infections de choléra, (3) l'évolution et l'écologie de l'antibiorésistance, (4) des mesocosmes semi-naturels au LEAP. |
Lab BBQ 2019
Dr. Levade thesis defence celebration. How it started...
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We are here // Nous sommes ici :
- McGill Genome Centre, 740 avenue Dr Penfield, Montreal, QC
- UdeM: Campus MIL, 1375 avenue Thérèse-Lavoie-Roux, Montreal, QC
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... and how it ended.
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